Cancer genes and hematopoiesis

PERSPECTIVE Cancer Genes and Hematopoiesis

B LOOD CELLS and their progenitors have been the proving ground for many ideas about development and differentiation, growth factors and receptors, transcriptional control, and normal and cancerous growth.’ Because leukemias, both human and experimental, are especially accessible cancers, they have provided many of the cancer genes and oncogenic mechanisms that we know the most about.’ An abidi...

Trithorax group genes in hematopoiesis

Hematopoietic stem and progenitor cells maintain blood homeostasis by giving rise to all mature blood cells and lymphocytes. A recent study identified the trithorax group gene ash1l as a critical regulator of quiescence and self-renewal potential in adult hematopoietic stem cells [1]. Ash1l encodes a large protein with histone methyltransferase activity that cooperates with the leukemia-associa...

Homeobox genes in normal hematopoiesis and leukemia.

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Neural Regulation of Hematopoiesis, Inflammation, and Cancer

Although the function of the autonomic nervous system (ANS) in mediating the flight-or-fight response was recognized decades ago, the crucial role of peripheral innervation in regulating cell behavior and response to the microenvironment has only recently emerged. In the hematopoietic system, the ANS regulates stem cell niche homeostasis and regeneration and fine-tunes the inflammatory response...

Autonomic regulation of hematopoiesis and cancer.